Is hexachlorophene safe in toothpaste?
Is hexachlorophene safe in toothpaste?
It has been used in a wide range of products varying from toothpaste and deodorants to feminine-hygiene solutions. While hexachlorophene is a relatively safe compound when used externally, ingestion can cause death.
What is the formula of hexachlorophene?
C13H6Cl6O2
Hexachlorophene/Formula
Why was hexachlorophene banned?
As a result of investigations of the toxicity of hexachlorophene in animals and reports of accidental intoxication in France, the FDA in 1972 banned all non-prescription uses of this drug, restricting hexachlorophene to prescription use only, as a surgical scrub and hand-wash product for health-care personnel.
What products contain hexachlorophene?
Hexachlorophene is used as a topical anti-infective, anti-bacterial agent in medicines. It is also found in soaps, toothpastes, and in the agricultural industry as a soil fungicide, plant bactericide, and acaricide.
Is Phisohex safe?
Phisohex is intended for external use only. If swallowed, Phisohex is harmful, especially to infants and children. Phisohex should not be poured into measuring cups, medicine bottles, or similar containers since it may be mistaken for baby formula or other medications.
Is Phisohex still made?
Sanofi-Aventis discontinued production of several forms of pHisoHex in August 2009 and discontinued all production of pHisoHex in September 2013). The formula for Dial soap was modified to remove hexachlorophene after the FDA ended over-the-counter availability in 1972.
What is the purpose of triclosan?
Triclosan is an ingredient added to many consumer products intended to reduce or prevent bacterial contamination. It is added to some antibacterial soaps and body washes, toothpastes, and some cosmetics—products regulated by the U.S. Food and Drug Administration (FDA).
How is hexachlorophene used as an antiseptic?
Hexachlorophene is a chlorinated bisphenol antiseptic agent with bacteriostatic activity. Hexachlorophene is used topically in soaps, creams and dermatological preparations and is active against gram-positive organisms, but much less effective against gram-negative organisms. (NCI05) Hexachlorophene is an Antiseptic.
Which is the hydroxy group of hexachlorophene?
Hexachlorophene is an organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6.
What is the safe level of hexachlorophene in blood?
Whole Blood Reference Ranges: Normal – less than 0.03 mg/ cu ml; Exposed – People using mouthwash containing 0.5% hexachlorophene for 3 weeks, avg concentration 0.06 mg/cu mL; Toxic – level of 0.78 mg/mL was found in a child who died, however adults with levels as high as 2.16 mg/mL have been asymptomatic.
What is the concentration of hexachlorophene in the brain?
Brain succinate dehydrogenase (SDH) activity was inhibited by in vitro hexachlorophene (HCP) with a half inhibitory concentration (IC50) of 0.65 x 10(-3) M. The HCP exerted noncompetitive inhibition at 0.5 mM ( IC50) on SDH activity. The brain SDH demands more energy of activation (deltaE) in the presence of HCP.